:root {
  --bg: #f6f7f5;
  --surface: #ffffff;
  --ink: #1f2427;
  --muted: #5d676d;
  --line: #e2e6e3;
  --brand: #2f3437;
  --accent: #2e9d6b;
  --warn-bg: #fff6e0;
  --warn-ink: #7a5300;
  --alarm: #b3261e;
  --grade-A: #1e8e57;
  --grade-B: #5aa832;
  --grade-C: #c9a227;
  --grade-D: #c97a27;
  --grade-E: #8a8f93;
}

* { box-sizing: border-box; }

body {
  margin: 0;
  font-family: system-ui, -apple-system, "Segoe UI", Roboto, sans-serif;
  background: var(--bg);
  color: var(--ink);
  line-height: 1.5;
}

h1, h2, h3 { margin: 0; line-height: 1.25; }

.topbar {
  display: flex; align-items: center; justify-content: space-between;
  gap: 16px; padding: 14px 24px; background: var(--brand); color: #fff;
}
.brand { display: flex; align-items: center; gap: 14px; color: inherit; text-decoration: none; }
.brand:hover .brand-mark { background: rgba(46,157,107,.25); }
.brand-mark {
  font-weight: 700; letter-spacing: .04em; padding: 6px 10px;
  border: 2px solid var(--accent); border-radius: 8px; color: #fff;
}
.brand h1 { font-size: 1.15rem; }
.subtitle { margin: 2px 0 0; font-size: .85rem; color: #c9d0d3; }
.lang { display: flex; gap: 4px; }
.lang a {
  color: #c9d0d3; text-decoration: none; font-size: .85rem;
  border: 1px solid #6b7478; border-radius: 6px; padding: 3px 8px;
}
.lang a.on { color: #fff; border-color: var(--accent); background: rgba(46,157,107,.2); }

.demo-banner {
  background: var(--warn-bg); color: var(--warn-ink);
  padding: 8px 24px; font-size: .85rem; border-bottom: 1px solid #f1dfae;
}

.layout {
  display: grid; grid-template-columns: 240px minmax(0, 1fr) 260px;
  gap: 20px; padding: 20px 24px; max-width: 1400px; margin: 0 auto;
}

.sidebar, .avatar {
  background: var(--surface); border: 1px solid var(--line);
  border-radius: 12px; padding: 14px; align-self: start;
}
.search {
  width: 100%; padding: 8px 10px; border: 1px solid var(--line);
  border-radius: 8px; font: inherit; margin-bottom: 10px;
}
.dolencias { list-style: none; margin: 0; padding: 0; }
.dolencias li a, .dolencias li .disabled {
  padding: 8px 10px; border-radius: 8px; color: var(--ink); text-decoration: none;
  display: flex; justify-content: space-between; gap: 8px;
}
.dolencias li a:hover { background: var(--bg); }
.dolencias li a.active { background: #e7f4ed; font-weight: 600; }
.dolencias li .disabled { color: var(--muted); }
.dolencias small { color: var(--muted); font-size: .75rem; white-space: nowrap; }

.content { min-width: 0; }
.ficha-head {
  background: var(--surface); border: 1px solid var(--line);
  border-radius: 12px; padding: 18px 20px; margin-bottom: 16px;
}
.ficha-head h2 { font-size: 1.6rem; }
.code { color: var(--muted); font-size: .85rem; }
.content-note { color: var(--muted); font-size: .8rem; margin-top: 8px; }

.filters { display: flex; flex-wrap: wrap; align-items: center; gap: 6px; margin: 14px 0 0; }
.filters span { font-size: .85rem; color: var(--muted); margin-right: 4px; }
.chip {
  border: 1px solid var(--line); background: var(--surface); border-radius: 999px;
  padding: 4px 10px; font-size: .8rem; color: var(--ink); text-decoration: none;
}
.chip.on { border-color: var(--ink); background: var(--ink); color: #fff; }

.grade {
  display: inline-flex; align-items: center; justify-content: center;
  min-width: 26px; height: 26px; border-radius: 6px;
  color: #fff; font-weight: 700; font-size: .85rem;
}
.grade-A { background: var(--grade-A); }
.grade-B { background: var(--grade-B); }
.grade-C { background: var(--grade-C); }
.grade-D { background: var(--grade-D); }
.grade-E { background: var(--grade-E); }

.disciplina {
  background: var(--surface); border: 1px solid var(--line);
  border-radius: 12px; padding: 14px 20px; margin-bottom: 12px;
}
.disciplina h3 { font-size: 1rem; margin-bottom: 8px; }
.sol { display: grid; grid-template-columns: 32px 1fr; gap: 10px; padding: 10px 0; border-top: 1px solid var(--line); }
.sol:first-of-type { border-top: 0; }
.sol-name { font-weight: 600; }
.sol-grade-label { color: var(--muted); font-size: .8rem; font-weight: 400; margin-left: 6px; }
.sol p { margin: 2px 0; }
.sol .fuente { color: var(--muted); font-size: .8rem; }
.tag {
  display: inline-block; font-size: .72rem; padding: 1px 8px; border-radius: 999px;
  background: #eef0f1; color: var(--muted); margin-left: 6px;
}

.avanzadas { border-color: #b9dcc9; background: #f3faf6; }
.estado { font-size: .75rem; padding: 2px 8px; border-radius: 999px; font-weight: 600; }
.estado-aprobada { background: #d7efe2; color: #156b42; }
.estado-en_ensayo { background: #e3ecfa; color: #24508f; }
.estado-experimental { background: #f4e4f6; color: #7a2e86; }

.seguridad { border-color: #f0c9c6; }
.seg { padding: 6px 0; }
.seg b.alarm { color: var(--alarm); }

.term {
  border: 0; background: none; padding: 0; font: inherit; color: var(--accent);
  border-bottom: 1px dotted var(--accent); cursor: pointer;
}

.avatar h2 { font-size: 1rem; margin-bottom: 6px; }
.avatar p { font-size: .85rem; color: var(--muted); }
.avatar-input { display: flex; gap: 6px; }
.avatar-input input { flex: 1; min-width: 0; padding: 8px; border: 1px solid var(--line); border-radius: 8px; font: inherit; }
.avatar-input button { border: 0; border-radius: 8px; padding: 0 12px; background: var(--line); }

.footer { text-align: center; color: var(--muted); font-size: .8rem; padding: 10px 24px 30px; }

.drawer {
  position: fixed; top: 0; right: 0; height: 100%; width: min(420px, 100%);
  background: var(--surface); border-left: 1px solid var(--line);
  box-shadow: -8px 0 24px rgba(0,0,0,.08); padding: 18px 22px; overflow-y: auto; z-index: 10;
}
.drawer-head { display: flex; justify-content: space-between; align-items: center; margin-bottom: 14px; }
.drawer-title { font-size: .8rem; text-transform: uppercase; letter-spacing: .06em; color: var(--muted); }
.drawer h3 { font-size: 1.3rem; margin-bottom: 8px; }
.link { border: 0; background: none; color: var(--accent); font: inherit; cursor: pointer; padding: 0; }
.link:disabled { color: var(--line); cursor: default; }

@media (max-width: 1050px) {
  .layout { grid-template-columns: 220px minmax(0, 1fr); }
  .avatar { grid-column: 1 / -1; }
}
@media (max-width: 720px) {
  .layout { grid-template-columns: 1fr; padding: 16px; }
  .topbar { padding: 12px 16px; }
  .demo-banner { padding: 8px 16px; }
}

.ensayos { margin-top: 6px; font-size: .85rem; }
.ensayos summary { cursor: pointer; color: var(--accent); }
.ensayos ul { margin: 6px 0; padding-left: 18px; }
.ensayos li { margin-bottom: 6px; }
.ensayos a { color: var(--accent); }
.ensayo-titulo { color: var(--muted); font-size: .8rem; }

.tag-ejemplo { background: #fff1d6; color: #7a5300; }
.tag-revision { background: #e3ecfa; color: #24508f; }
.evidencia { font-size: .8rem; color: var(--muted); margin-top: 2px; }
.evidencia summary { cursor: pointer; }
.evidencia ul { margin: 6px 0; padding-left: 18px; }
.evidencia a, .seg-fuente { color: var(--accent); }
.cita { color: var(--ink); margin-top: 2px; }
.seg-fuente { font-size: .78rem; margin-left: 6px; }

.seg-grupo { border-top: 1px solid var(--line); padding: 6px 0; }
.seg-grupo summary { cursor: pointer; font-weight: 600; }
.seg-grupo .seg { padding-left: 14px; }

/* Vista de revisión */
.rev-main { max-width: 1100px; margin: 0 auto; padding: 20px 24px; }
.rev-tabla { width: 100%; border-collapse: collapse; background: var(--surface); }
.rev-tabla th, .rev-tabla td { border: 1px solid var(--line); padding: 8px 10px; text-align: left; }
.rev-seccion { margin: 24px 0 10px; }
.rev-item { border-top: 1px solid var(--line); padding: 12px 0; }
.rev-item:first-of-type { border-top: 0; }
.estado-rev-revisado { border-left: 4px solid var(--grade-A); padding-left: 10px; }
.estado-rev-rechazado { border-left: 4px solid var(--alarm); padding-left: 10px; opacity: .7; }
.rev-motivo { font-size: .85rem; color: var(--muted); }
.rev-evidencias { font-size: .82rem; padding-left: 18px; }
.rev-evidencias a { color: var(--accent); }
.rev-form { display: flex; flex-wrap: wrap; gap: 6px; margin-top: 8px; }
.rev-form input[type=text] { flex: 1; min-width: 200px; padding: 6px 8px; border: 1px solid var(--line); border-radius: 6px; font: inherit; }
.rev-form button { border: 0; border-radius: 6px; padding: 6px 12px; cursor: pointer; font: inherit; }
.btn-ok { background: var(--grade-A); color: #fff; }
.btn-ko { background: var(--alarm); color: #fff; }
.btn-neutro { background: var(--line); }
.rev-meta { font-size: .78rem; color: var(--muted); margin-top: 4px; }
.tag-revisado { background: #d7efe2; color: #156b42; }

/* Nutrición por biomarcador */
.layout-2 { grid-template-columns: 240px minmax(0, 1fr); max-width: 1150px; }
.side-title { font-size: .8rem; text-transform: uppercase; letter-spacing: .06em; color: var(--muted); margin: 2px 0 8px; }
.side-back { font-size: .85rem; margin: 12px 0 0; }
.side-back a, .side-link { color: var(--accent); }
.side-link { display: block; font-size: .9rem; font-weight: 600; text-decoration: none; padding: 6px 10px; margin-bottom: 8px;
  border: 1px solid #b9dcc9; border-radius: 8px; background: #f3faf6; }
.rangos { margin-top: 12px; }
.rangos-title { font-size: .85rem; color: var(--muted); margin-bottom: 6px; }
.rangos-barra { display: grid; grid-auto-flow: column; grid-auto-columns: 1fr; gap: 4px; }
.rango { border-radius: 8px; padding: 8px 10px; font-size: .85rem; border: 2px solid transparent; }
.rango b { display: block; }
.rango-normal { background: #e3f3ea; color: #156b42; }
.rango-vigilar { background: #fdf3d8; color: #7a5300; }
.rango-alto { background: #fbe4e2; color: #8e1f18; }
.rango.marcado { border-color: currentColor; box-shadow: 0 0 0 2px rgba(0,0,0,.05); }
.valor { display: flex; align-items: center; gap: 10px; margin-top: 12px; font-size: .9rem; }
.valor input { width: 140px; padding: 6px 8px; border: 1px solid var(--line); border-radius: 8px; font: inherit; }
.valor-nota { font-size: .75rem; color: var(--muted); margin-top: 4px; }
.valor-resultado { margin-top: 8px; font-weight: 600; }
.efecto-cifra { float: right; font-weight: 700; font-size: .95rem; color: var(--grade-A); white-space: nowrap; }
.efecto-cifra.sin-cifra { color: var(--muted); font-weight: 400; font-size: .8rem; }
.sin-efecto summary { cursor: pointer; }
.sin-efecto summary h3 { display: inline; }
.orden-nota { margin-top: 8px; }
.aviso-link { color: var(--alarm) !important; }
.aviso-medico { background: var(--warn-bg); color: var(--warn-ink); border: 1px solid #f1dfae; border-radius: 12px; padding: 12px 16px; font-size: .88rem; }
@media (max-width: 720px) {
  .rangos-barra { grid-auto-flow: row; }
  .efecto-cifra { float: none; display: block; }
}

/* Chat con la IA en la ficha */
.avatar { position: sticky; top: 16px; max-height: calc(100vh - 32px); display: flex; flex-direction: column; }
.chat-log { flex: 1; overflow-y: auto; display: flex; flex-direction: column; gap: 8px; margin: 6px 0 10px; min-height: 60px; }
.msg { font-size: .86rem; border-radius: 10px; padding: 8px 10px; line-height: 1.45; }
.msg p { margin: 0 0 6px; color: var(--ink); font-size: .86rem; }
.msg p:last-child { margin-bottom: 0; }
.msg ul { margin: 4px 0 6px; padding-left: 18px; }
.msg-yo { align-self: flex-end; background: var(--brand); color: #fff; max-width: 90%; }
.msg-ia { background: var(--bg); border: 1px solid var(--line); }
.msg-pensando { color: var(--muted); font-style: italic; }
.msg-sin-datos { border-color: #f1dfae; background: var(--warn-bg); }
.cita-n {
  display: inline-block; min-width: 16px; padding: 0 4px; margin: 0 1px; border-radius: 4px;
  background: #d7efe2; color: #156b42; font-size: .7rem; font-weight: 700; text-align: center;
  text-decoration: none; vertical-align: super; line-height: 1.4;
}
.msg-fuentes { margin-top: 6px; font-size: .76rem; color: var(--muted); }
.msg-fuentes summary { cursor: pointer; }
.msg-fuentes ol { margin: 4px 0 0; padding-left: 22px; }
.msg-fuentes a { color: var(--accent); }
.chat-ejemplos { display: flex; flex-wrap: wrap; gap: 4px; margin-bottom: 8px; }
.chat-ejemplo { cursor: pointer; font: inherit; font-size: .75rem; }
.avatar-input button { background: var(--accent); color: #fff; cursor: pointer; }
.avatar-input button:disabled { background: var(--line); cursor: default; }
@media (max-width: 1050px) { .avatar { position: static; max-height: none; } .chat-log { max-height: 420px; } }